[Clinical practice guideline for nasal allergen provocation test in children (2025)]

Area of Science:

• Pediatric Allergy and Immunology
• Otorhinolaryngology
• Clinical Guideline Development

Background:

• Pediatric allergic rhinitis (AR) incidence is rising, impacting children's quality of life and increasing healthcare burdens.
• The nasal allergen provocation test (NAPT) is vital for diagnosing AR and local allergic rhinitis (LAR), guiding personalized treatments.
• A lack of standardized NAPT protocols in China hinders its clinical application in pediatric AR management.

Purpose of the Study:

• To establish a unified, standardized guideline for the clinical application of NAPT in pediatric AR diagnosis and management in China.
• To promote accurate diagnosis and individualized treatment strategies for children with AR.
• To provide a scientific, practical, and highly applicable resource for clinicians.

Main Methods:

• A multidisciplinary nominal group approach was employed.
• Experts in otorhinolaryngology, allergy, pediatrics, and methodology collaborated.
• The guideline systematically addresses NAPT indications, contraindications, agents, procedures, assessment, interpretation, and safety.

Main Results:

• Development of a comprehensive guideline for NAPT in pediatric AR.
• Standardized protocols for NAPT procedures, including administration, assessment, and interpretation.
• Recommendations for safety management during NAPT.

Conclusions:

• The guideline provides a standardized framework for NAPT in pediatric AR diagnosis and management in China.
• Implementation of this guideline is expected to improve diagnostic accuracy and support individualized patient care.
• This initiative aims to enhance the clinical practice of NAPT for pediatric allergic rhinitis nationwide.