[Advances in molecular mechanisms of atmospheric ozone exposure affecting glucose metabolic homeostasis]

In recent years, the disease burden associated with impaired glucose homeostasis has increased substantially both globally and in China, making it a major public health concern. Impaired glucose homeostasis is influenced not only by biological factors but also closely linked to environmental factors such as air pollution. Numerous studies have explored the association between ozone (O₃) exposure and dysregulated glucose homeostasis. Key mechanisms identified include oxidative stress, inflammation, metabolic reprogramming, neuroendocrine regulation, and gut microbiota. This review systematically summarizes recent advances in the pathways through which O₃ exposure affects glucose metabolic regulation, aiming to provide a scientific basis for developing effective interventions and strategies.