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Related Experiment Video

Updated: Mar 21, 2026

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Biomarkers in Diabetic Foot.

Hojin Lee1, Alexandra Brown2, Garneisha M Torrence3

  • 1Division of Vascular Surgery, University of Michigan Health, Ann Arbor, MI, USA.

Clinics in Podiatric Medicine and Surgery
|March 19, 2026
PubMed
Summary
This summary is machine-generated.

Diabetic foot ulcers (DFU) are common diabetes complications. Integrating biomarkers for inflammation, oxidative stress, and metabolism can improve DFU diagnosis, prognosis, and treatment, reducing amputation risk.

Keywords:
BiomarkersDiabetic foot ulcers (DFU)Glycemic controlInflammationWound healing

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Area of Science:

  • Endocrinology and Metabolism
  • Wound Healing Research
  • Biomarker Discovery

Background:

  • Diabetes mellitus impacts nearly 600 million adults globally.
  • Diabetic foot ulcers (DFU) are a frequent complication, stemming from neuropathy, ischemia, infection, and poor healing.
  • Biomarkers are crucial for early DFU diagnosis, risk assessment, and management.

Purpose of the Study:

  • To review the role of various biomarkers in diabetic foot ulcer management.
  • To highlight the potential of integrating multiple biomarker types for personalized DFU care.

Main Methods:

  • Literature review of studies on biomarkers in DFU.
  • Analysis of inflammatory markers (CRP, IL-6, TNF-α).
  • Assessment of oxidative stress indicators (MDA, 8-OHdG) and metabolic markers (HbA1c, glucose, CGM).

Main Results:

  • Chronic inflammation and cellular damage in nonhealing wounds are indicated by CRP, IL-6, TNF-α, MDA, and 8-OHdG.
  • Wound surface area trends and metabolic markers like HbA1c and glucose inform prognosis.
  • Combined biomarker data can guide personalized treatment strategies.

Conclusions:

  • Integrating inflammatory, oxidative stress, and metabolic biomarkers offers a comprehensive approach to DFU management.
  • Personalized interventions based on biomarker profiles may reduce DFU-related morbidity and amputation rates.
  • Further research into integrated biomarker panels is warranted for clinical application.