Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cleavage and Blastulation

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

Gastrulation

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...

Zygotic Development And Stem Cell Formation

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dual role of Oct4 and Sox2 in controlling the developmental capacity and timing of tissue morphogenesis in the embryonic lineage.

Developmental cell·2025

Same author

Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation.

Proceedings of the National Academy of Sciences of the United States of America·2023

Same author

Pretreatment with intravenous levetiracetam in the rhesus monkey Coriaria lactone-induced status epilepticus model.

Journal of the neurological sciences·2015

Same author

Apolipoprotein 4 may increase viral load and seizure frequency in mesial temporal lobe epilepsy patients with positive human herpes virus 6B.

Neuroscience letters·2015

Same author

[Analytical studies on flavonoids constituents in Apocynum venetom leaves by UPLC-Q-TOF-MS].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials·2015

Same author

[Clinicopathological analysis of typical carcinoid primarily originated from middle ear, sphenoid and throat].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2015

Same journal

Building a resilient ovarian reserve: Early soma-oocyte interactions.

Current topics in developmental biology·2026

Same journal

Role of macrophages in testis function.

Current topics in developmental biology·2026

Same journal

Role of retinoic acid in meiosis.

Current topics in developmental biology·2026

Same journal

Impact of cancer immunotherapies on oocyte health and ovarian function.

Current topics in developmental biology·2026

Same journal

The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan.

Current topics in developmental biology·2026

Same journal

Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles.

Current topics in developmental biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 21, 2026

Imaging Cell Shape Change in Living Drosophila Embryos

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

Cell shape dynamics during mouse peri-implantation development and embryo dormancy.

Deepthi Chandramohan¹, Fei Chen¹, Rui Chen¹

¹Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

Current Topics in Developmental Biology

|March 19, 2026

Summary

This summary is machine-generated.

Mammalian embryo implantation involves complex cell shape and tissue changes. This review covers peri-implantation development and embryo dormancy, highlighting ongoing morphogenesis during diapause.

Keywords:

Blastocyst Cavity Cell shape Diapause Dormancy Egg cylinder Embryo Implantation Lumenogenesis Morphogenesis

More Related Videos

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Related Experiment Videos

Last Updated: Mar 21, 2026

Imaging Cell Shape Change in Living Drosophila Embryos

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos

Published on: February 22, 2016

Area of Science:

Developmental biology
Reproductive biology
Cell biology

Background:

Mammalian embryo implantation is a critical process where the blastocyst interacts with maternal uterine tissues.
This interaction initiates the transformation into a post-implantation conceptus, essential for placentation and fetal development.
Peri-implantation embryogenesis involves coordinated growth, morphogenesis, and cell fate transitions in embryonic and extra-embryonic tissues.

Purpose of the Study:

To review murine blastocyst formation.
To focus on cell shape and tissue dynamics during peri-implantation embryogenesis.
To synthesize current knowledge on tissue morphogenesis during embryo dormancy.

Main Methods:

Literature review of murine blastocyst formation.
Analysis of cell shape and tissue dynamics during peri-implantation development.
Synthesis of research on tissue morphogenesis in dormant embryos.

Main Results:

Embryo implantation involves significant changes in cell shape and tissue architecture.
Embryonic development can enter a dormant state (diapause) in some species, like mice.
Even during diapause, slow morphogenetic changes continue to occur within the embryo.

Conclusions:

Peri-implantation embryogenesis is a dynamic process requiring coordinated tissue morphogenesis.
Embryo dormancy (diapause) is characterized by developmental arrest but not a cessation of all morphogenetic activity.
Understanding tissue dynamics during diapause is crucial for comprehending reproductive strategies and developmental plasticity.