Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomic DNA in Prokaryotes

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...

Genomic DNA in Eukaryotes

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

DNA-only Transposons

DNA-only Transposons

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...

Horizontal Gene Transfer

Horizontal Gene Transfer

Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

Evolution of Microbial Genome

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Statistical limits and conditional complexity in real-world reinforcement learning: a tutorial survey.

Frontiers in artificial intelligence·2026

Same author

Integrated lipidomic and transcriptomic profiling of the host response in human malaria.

Genome biology·2026

Same author

Post-transcriptional RNA-mediated regulation in infection: mechanisms, functions, and analytical approaches.

Trends in parasitology·2026

Same author

Integrative proteomics to illuminate host-parasite interactions in malaria.

Trends in parasitology·2026

Same author

The Global Landscape of <i>Plasmodium falciparum</i> Drug Resistance Markers, 2005-2025: A Systematic Review and Meta-Analysis.

Pathogens (Basel, Switzerland)·2026

Same author

Federated single-cell QTL meta-analysis reveals novel disease mechanisms.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

Toward global representation in single-cell genomics.

Tala Shahin¹, Dariga Bolatbay¹, Youssef Idaghdour²

¹Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, P.O. Box 129188, United Arab Emirates.

Trends in Genetics : TIG

|March 19, 2026

Summary

This summary is machine-generated.

Single-cell genomics needs diverse data to avoid bias. Incorporating global genetic and environmental contexts is crucial for accurate human biology insights and equitable health benefits.

Keywords:

diversity environment ethnicity genetic ancestry lifestyle single-cell genomics

More Related Videos

Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

Published on: October 31, 2025

Related Experiment Videos

Last Updated: Jun 30, 2026

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

Published on: October 31, 2025

Area of Science:

Genomics
Human Biology
Population Health

Background:

Single-cell genomics offers high-resolution insights into cellular heterogeneity.
Current datasets lack diversity, primarily from limited genetic, environmental, and sociocultural contexts.
This data imbalance hinders understanding context-specific effects and biases global applications.

Purpose of the Study:

To highlight the critical need for diversity in single-cell genomics datasets.
To advocate for diversity as a fundamental study design principle.
To ensure equitable global health benefits from single-cell genomics.

Main Methods:

Review of existing single-cell genomics data limitations.
Argument for integrating diversity into study design, reference atlases, and data standards.
Proposal of actionable strategies for creating diverse, population-specific resources.

Main Results:

Current single-cell genomics data is not globally representative.
Lack of diversity obscures context-specific biological variations.
Biases in atlases and predictive tools limit the scope and applicability of findings.

Conclusions:

Diversity must be a core principle in single-cell genomics research.
Implementing strategies for diverse data collection is essential for robust biological inference.
Achieving global relevance requires dedicated efforts to include varied populations and contexts.