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Prevalence of comorbidities and medication use in progressive systemic sclerosis in northeast Mexico

Jorge Armando Hermosillo-Villafranca¹, Maria Joselin Rodarte-Gallegos²

¹Servicio de Reumatología, Hospital general de Zona #11, Instituto Mexicano del Seguro Social, Piedras Negras, Coahuila, Mexico.

Reumatologia Clinica

|March 19, 2026

Abstract

Background:

Systemic sclerosis (SSc) is characterized by exuberant fibrosis, caused by severe vasculopathy and vasospasm. Despite the impact of the disease on survival, epidemiological and comorbidity data on SSc are currently limited in Mexico.

Methods:

Observational, cross-sectional, and descriptive clinical study. Patients with SSc according to the 2013 ACR/EULAR criteria from 2 public healthcare centres in northeastern Mexico from the IMSS were included. Sociodemographic, clinical, and laboratory variables were collected. The prevalence of comorbidities reported by the patients was investigated. Serology, transthoracic ultrasound, and high-resolution chest computed tomography were performed.

Results:

68 patients with SSc were included: 65 (95.3%) women, with a mean age of 51.5 ± 9.86 years, with the following distribution: 50 (73.5%) limited, 7 (10.3%) diffuse, 11 overlap (16.2%), 22 (32.3%) with systemic arterial hypertension, 14 (20.5%) with obesity.

Conclusions:

The detection of systemic arterial hypertension, the most frequent comorbidities in multiple populations, could prevent cardiovascular complications.

Keywords:

Comorbidity Comorbilidad Epidemiology Epidemiología Esclerodermia Esclerosis sistémica Hipertensión arterial sistémica Scleroderma Systemic arterial hypertension Systemic sclerosis

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