CRISPR-enhanced microalgae biosynthesis: a promising approach for future functional feed ingredients.

Area of Science:

• Biotechnology
• Agricultural Science
• Marine Biology

Background:

• Microalgae produce valuable bioactive compounds like proteins, lipids, and vitamins.
• These natural products offer superior nutritional and health benefits for livestock compared to synthetic alternatives.
• Current commercial microalgae production cannot meet the growing demand for these compounds.

Purpose of the Study:

• To review applications of microalgae in livestock production.
• To explore synthetic biology strategies, focusing on CRISPR, for enhancing microalgae cell factories.
• To highlight advancements in optimizing microalgae for improved nutritional profiles and livestock utilization.

Main Methods:

• Review of current literature on microalgae applications in livestock.
• Analysis of synthetic biology tools, with emphasis on CRISPR genome editing.
• Examination of critical pathway nodes in microalgae biosynthesis.
• Assessment of recent progress in microalgae utilization for animal feed and health.

Main Results:

• Synthetic biology, especially CRISPR, offers powerful tools to engineer microalgae.
• Genome editing can optimize microalgae for enhanced production of specific bioactive compounds.
• Microalgae show significant promise for improving livestock growth, health, and nutritional value.

Conclusions:

• CRISPR-based genome editing is key to unlocking the full potential of microalgae cell factories.
• Increased microalgae production through synthetic biology is vital for sustainable livestock farming.
• Further research will drive innovation in microalgae-derived products for enhanced animal nutrition and welfare.