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Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory

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Smoking cessation with CBT and mindfulness: study protocol for a randomized controlled trial.

Rongrong Chen¹, Ruihuan Ye¹, Yanhui Liao²

¹Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, Zhejiang, 310016, People's Republic of China.

|March 20, 2026

Summary

This study tested cognitive behavioral therapy (CBT) with mindfulness audio for smoking cessation. The combined approach may improve quitting success and emotional regulation in adult smokers.

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Area of Science:

Digital Health Interventions
Behavioral Psychology
Public Health

Background:

Tobacco smoking is a major global health concern, leading to significant morbidity and mortality.
Smoking cessation is challenging due to cravings and emotional distress.
Mindfulness techniques integrated with Cognitive Behavioral Therapy (CBT) may enhance cessation outcomes.

Purpose of the Study:

To evaluate the efficacy of a combined CBT text and mindfulness audio program for smoking cessation.
To assess the impact of the intervention on smoking frequency, craving intensity, and emotional regulation.
To explore secondary outcomes including sleep quality, nicotine dependence, and weight changes.

Main Methods:

A parallel-group, assessor-blinded randomized controlled trial (RCT) involving approximately 2000 adult smokers in China.
Participants were randomized to receive either CBT text only (Group A) or CBT text plus mindfulness audio (Group B) for 8 weeks.
Primary outcomes measured were smoking frequency, craving intensity, and emotional regulation, with follow-up to 26 weeks. Data collected via online questionnaires and cotinine tests.

Main Results:

The study is currently enrolling participants and has not yet yielded results.
Data collection and analysis are ongoing to determine the primary and secondary outcomes.
The trial is registered (NCT06901713) and ethical approval has been obtained.

Conclusions:

The findings are expected to contribute to the development of more effective digital health interventions for smoking cessation.
This research may provide insights into the synergistic effects of CBT and mindfulness for overcoming smoking addiction.
The study aims to offer evidence-based strategies for public health initiatives targeting smoking cessation.