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Benoxinate-Induced Keratopathy: Clinical Patterns and Management, a Cairo University Residents' Report
Maryam Massoud1, Rawan Hosny, Rana Shebl
1Department of Ophthalmology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt .
Eye & Contact Lens
|March 20, 2026
Summary
Benoxinate-induced keratopathy, a severe eye condition, can lead to vision loss, particularly in welders. Early detection and intervention are crucial for managing this preventable disease.
Area of Science:
- Ophthalmology
- Corneal Diseases
- Toxicology
Background:
- Benoxinate hydrochloride 0.4% is used for ophthalmic procedures.
- Prolonged use can lead to serious corneal complications.
- Benoxinate-induced keratopathy is a significant concern in occupational settings like welding.
Purpose of the Study:
- To characterize the clinical features of benoxinate-induced keratopathy.
- To identify patterns of corneal damage and complications.
- To evaluate management strategies for this condition.
Main Methods:
- Retrospective single-center study.
- Inclusion criteria: patients using benoxinate >1 month with keratopathy or corneal complications.
- 36 eyes were analyzed.
Main Results:
- 90.5% of affected individuals were welders.
- High prevalence of secondary corneal abscess (47.2%) and ring-shaped corneal deposits (66.7%).
- Significant rates of corneal perforation (13.9%) and thinning (22.3%) at presentation; epithelial defects were common.
- Management choice correlated with epithelial defect size and visual acuity; visual acuity did not improve post-healing.
Conclusions:
- Benoxinate-induced keratopathy is a preventable, potentially blinding condition.
- Urgent need for stricter regulations on over-the-counter availability of benoxinate.
- Occupational screening and awareness are vital for prevention.
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