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Inflammatory Bowel Disease in Patients With Atopic Dermatitis and Allergic Rhinitis: A Nationwide Case-Control Study
Chung-Fang Tseng1, Meng-Che Wu2,3,4, Yu-Hsun Wang5
1School of Public Health, Chung Shan Medical University, Taichung, Taiwan.
Introduction:
Inflammatory bowel disease (IBD) has been associated with several allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma. However, the correlations between these conditions vary-some are positively correlated, and some are negatively correlated. To address these discrepancies, this study explored the risk of IBD in patients with allergic diseases.
Methods:
Data were collected from the Taiwan National Health Insurance Research Database, which contains data on approximately 99% of Taiwan's population. Patients with new-onset IBD and matched controls were enrolled. Data on comorbidities, demographics, and corticosteroid use were collected. Statistical analysis included conditional logistic regression analysis.
Results:
In total, 300 patients with IBD and 2400 patients without IBD were enrolled. Atopic dermatitis (OR: 5.73, 95% CI: 1.69-19.48), allergic rhinitis (OR: 1.72, 95% CI: 1.06-2.79), chronic kidney disease (OR: 3.04, 95% CI: 1.15-8.04), and ischemic heart disease (OR: 1.97, 95% CI: 1.20-3.26) were associated with an increased risk of IBD. Among patients with atopic dermatitis or allergic rhinitis, the risk of IBD was higher for those aged < 65 years, men, or those not using corticosteroids.
Conclusion:
This study highlights an associated risk of IBD in patients with atopic dermatitis and allergic rhinitis.
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