Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Electrophysiology of Normal Cardiac Rhythm

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...

Cardiac Action Potential

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

Correlation between ECG and Cardiac Cycle

Correlation between ECG and Cardiac Cycle

The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preparation and characterization of visible-light-driven TiO2 photocatalyst Co-doped with nitrogen and erbium.

Journal of nanoscience and nanotechnology·2012

Same author

A novel sucrose phosphorylase from the metagenomes of sucrose-rich environment: isolation and characterization.

World journal of microbiology & biotechnology·2012

Same author

A metal-based inhibitor of tumor necrosis factor-α.

Angewandte Chemie (International ed. in English)·2012

Same author

[Effect of snail control of niclosamide by soil mixing and spraying methods in high dam of terrace].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2012

Same author

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency.

Neurobiology of aging·2012

Same author

[Down-regulation of transcription factor PU.1 via abnormal epigenetic modification in chronic myeloid leukemia].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2012

Same journal

Fusing Tool Segmentation Predictions from Pose-Informed Morphological Polar Transform of Endoscopic Images.

IEEE International Conference on Automation Science and Engineering (CASE) : [proceedings]. IEEE Conference on Automation Science and Engineering·2025

Same journal

Deep Learning-Enhanced Robotic Subretinal Injection with Real-Time Retinal Motion Compensation.

IEEE International Conference on Automation Science and Engineering (CASE) : [proceedings]. IEEE Conference on Automation Science and Engineering·2025

Same journal

Generating Counterfactual Explanations For Causal Inference in Breast Cancer Treatment Response.

IEEE International Conference on Automation Science and Engineering (CASE) : [proceedings]. IEEE Conference on Automation Science and Engineering·2024

Same journal

Particle Filter Based Active Localization of Target and Needle in Robotic Image-Guided Intervention Systems.

IEEE International Conference on Automation Science and Engineering (CASE) : [proceedings]. IEEE Conference on Automation Science and Engineering·2014

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 21, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Optimizing Network Simulation of Cardiac Electrical Dynamics.

Runsang Liu¹, Hui Yang¹

¹Complex System Monitoring, Modeling, and Control Laboratory, The Pennsylvania State University, University Park, PA 16802 USA.

IEEE International Conference on Automation Science and Engineering (CASE) : [Proceedings]. IEEE Conference on Automation Science and Engineering

|March 20, 2026

Summary

This summary is machine-generated.

This study introduces a statistical metamodeling framework to optimize cardiac electrical dynamics simulations. This approach efficiently calibrates complex network models by predicting simulation responses and guiding parameter selection for improved accuracy.

Keywords:

Simulation model cardiac electrophysiology heart simulation statistical model

More Related Videos

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Published on: January 8, 2013

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

Related Experiment Videos

Last Updated: Mar 21, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Published on: January 8, 2013

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

Area of Science:

Cardiology
Computational Biology
Biophysics

Background:

Network models effectively represent cardiac structural geometry for simulation.
Traditional calibration methods struggle with the complexity and computational cost of cardiac electrical dynamics.

Purpose of the Study:

To present a novel statistical metamodeling framework for optimizing network simulations of cardiac electrical dynamics.
To address the challenges of calibrating complex, computationally expensive cardiac models.

Main Methods:

Development of a statistical surrogate model to predict simulation responses across various parameter settings.
Leveraging uncertainty estimates from the metamodel to sequentially guide parameter selection for maximum expected improvement.
Iterative optimization process to efficiently identify optimal parameter settings for cardiac simulations.

Main Results:

The proposed statistical metamodeling approach efficiently calibrates network simulations of complex spatiotemporal cardiac dynamics.
Validation through case studies on 2D cardiac tissue and a whole heart model demonstrates effectiveness.

Conclusions:

Statistical metamodeling offers an efficient solution for calibrating complex cardiac network simulations.
The framework successfully optimizes the identification of parameter settings for accurate cardiac modeling.