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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Related Experiment Video

Updated: Mar 21, 2026

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
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Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

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Fibronectin-Based Skin Care Regimens for Skin Recovery After Intense Pulsed Light Therapy: A Split-Face Study.

Haixia Feng1, Lan Ge2, Ge Shi3,4

  • 1Department of Dermatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, People's Republic of China.

Clinical, Cosmetic and Investigational Dermatology
|March 20, 2026
PubMed
Summary
This summary is machine-generated.

A fibronectin serum effectively improved skin hydration and reduced redness after intense pulsed light (IPL) treatments. This skincare regimen enhanced skin radiance and barrier function with no reported adverse events.

Keywords:
fibronectinintense pulsed lightpost-treatment skincareskin barrier

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Area of Science:

  • Dermatology
  • Cosmetic Science
  • Skin Biology

Background:

  • Intense pulsed light (IPL) treatments can cause temporary skin issues like redness, dryness, and impaired barrier function.
  • Effective post-procedural skincare is crucial for mitigating these side effects and promoting skin recovery.

Purpose of the Study:

  • To evaluate the efficacy of a fibronectin-containing skincare regimen in restoring skin barrier function after IPL.
  • To assess the ability of fibronectin serum to alleviate common post-IPL side effects such as erythema and dryness.

Main Methods:

  • A 28-day, split-face clinical study involving 32 healthy female participants undergoing IPL treatment.
  • Application of a fibronectin serum on one side of the face and a control serum on the other.
  • Assessment of skin hydration, transepidermal water loss (TEWL), erythema, and radiance at multiple time points.

Main Results:

  • The fibronectin-treated side demonstrated significantly improved skin hydration and reduced TEWL compared to the control.
  • Significant improvements in skin radiance and erythema were observed on the fibronectin-treated side by days 7 and 28.
  • Both objective measurements and subjective assessments confirmed the superior performance of the fibronectin serum, with no adverse events reported.

Conclusions:

  • A fibronectin-containing serum is effective in improving skin hydration, reducing barrier dysfunction, and alleviating erythema post-IPL.
  • The serum also enhances skin radiance and is well-tolerated, supporting its use in post-IPL skincare.
  • Fibronectin serum shows potential as a valuable component of post-procedural skincare regimens following intense pulsed light therapy.