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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Secukinumab-Induced Delayed Behçet-Like Reaction in a Patient with Plaque Psoriasis: A Case Report
Yanjie Wei1, Peilian Zhang2, Jintao Chuan1
1Department of Dermatology, The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming, People's Republic of China.
Clinical, Cosmetic and Investigational Dermatology
|March 20, 2026
Summary
Secukinumab therapy for psoriasis can rarely cause a paradoxical Behçet's-like syndrome, characterized by ulcers and skin lesions. Early detection and drug discontinuation are key to managing this adverse reaction.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Psoriasis is a chronic autoimmune condition treated with biologics like secukinumab.
- Secukinumab targets interleukin-17 (IL-17), a key cytokine in psoriasis pathogenesis.
- Paradoxical reactions to biologics, though rare, require careful monitoring.
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