Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

11.1K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
11.1K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

9.1K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
9.1K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

75
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
75
Levels of Use of a GIS01:29

Levels of Use of a GIS

447
Geographic Information Systems (GIS) operate across three levels of application, each representing an increasing degree of complexity: data management, analysis, and prediction. These levels reflect the expanding functionality and versatility of GIS technology in handling spatial data for diverse purposes.Data ManagementAt its foundational level, GIS serves as a tool for data management, enabling the input, storage, retrieval, and organization of spatial data. This level is often employed in...
447
Microtubule Associated Proteins (MAPs)01:42

Microtubule Associated Proteins (MAPs)

6.3K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
6.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and Control of a 1-DOF MRI Compatible Pneumatically Actuated Robot with Long Transmission Lines.

IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division·2011
Same author

Effect of oxidized low-density lipoprotein concentration polarization on human smooth muscle cells' proliferation, cycle, apoptosis and oxidized low-density lipoprotein uptake.

Journal of the Royal Society, Interface·2011
Same author

Acrolein hydrogenation on Pt(211) and Au(211) surfaces: a density functional theory study.

Physical chemistry chemical physics : PCCP·2011
Same author

Anhydrous proton-conducting membrane based on poly-2-vinylpyridinium dihydrogenphosphate for electrochemical applications.

The journal of physical chemistry. B·2011
Same author

Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors.

European journal of medicinal chemistry·2011
Same author

Metabolomic study of insomnia and intervention effects of Suanzaoren decoction using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry.

Journal of pharmaceutical and biomedical analysis·2011
Same journal

Bioactive carbon dots from peony seed meal for nanomedicine via circular economy.

iScience·2026
Same journal

Genetic ablation of <i>Sfxn5</i> induces mitochondrial dysfunction and precipitates lethal metabolic crisis in mice.

iScience·2026
Same journal

Expansion, functional diversification, and gene fusion events in the Ato protein family.

iScience·2026
Same journal

The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasion.

iScience·2026
Same journal

Urbanization compound pathways of global lung cancer incidence risk under proximal and distal interactions.

iScience·2026
Same journal

Capsid and integrase play essential apposing roles in viral ribonucleoprotein assembly during HIV-1 core morphogenesis.

iScience·2026
See all related articles

Related Experiment Video

Updated: Mar 21, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.8K

AI-powered TargetMap: Enabling system-level target discovery through full-path reasoning on a unified knowledge

Xizhi Jin1,2, Sijie Wang1, Jiahe Chen3

  • 1College of Pharmaceutical Sciences, Zhejiang University, 886 Yuhangtang Road, Hangzhou, Zhejiang 310058, P.R. China.

Iscience
|March 20, 2026
PubMed
Summary
This summary is machine-generated.

TargetMap, an AI platform, enhances drug discovery by using large language models (LLMs) for system-wide biological network analysis. It generates testable hypotheses by understanding disease mechanisms beyond local patterns.

Keywords:
Applied sciencesNetwork

More Related Videos

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

1.1K
Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT
12:19

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

Published on: May 27, 2012

17.8K

Related Experiment Videos

Last Updated: Mar 21, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.8K
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

1.1K
Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT
12:19

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

Published on: May 27, 2012

17.8K

Area of Science:

  • Computational Biology
  • Pharmacology
  • Artificial Intelligence

Background:

  • Drug discovery faces high attrition rates due to incomplete understanding of biological networks.
  • Current computational tools like graph neural networks (GNNs) capture local patterns but miss global context in disease pathways.

Purpose of the Study:

  • Introduce TargetMap, an AI-driven knowledge graph platform.
  • Enable system-level understanding of disease pathology for improved therapeutic target identification.
  • Bridge the gap between local network analysis and mechanistic reasoning.

Main Methods:

  • Developed an AI platform, TargetMap, utilizing a large language model (LLM)-based full-path graph reasoning algorithm.
  • Represented biological pathways as structured knowledge graphs, processed as narratives for holistic analysis.
  • Integrated a unified knowledge base and Graph Retrieval-Augmented Generation (RAG) for comprehensive data handling.

Main Results:

  • TargetMap facilitates a system-level comprehension of disease pathology.
  • The platform enables the generation of testable hypotheses for therapeutic targets.
  • Achieved mechanistic reasoning by moving beyond traditional local network analysis.

Conclusions:

  • TargetMap offers a novel paradigm for drug discovery by integrating LLM-based reasoning with knowledge graphs.
  • The platform addresses limitations of existing computational tools in capturing global pathway context.
  • Facilitates hypothesis generation grounded in a holistic, system-level understanding of biological mechanisms.