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Updated: Mar 21, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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The LNK adaptor protein: a dual regulator of proliferation and migration in solid tumors

Jessica C Mantilla-Ollarves1,2, Laura Velazquez3, Leticia Rocha-Zavaleta1

  • 1Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México.

Molecular & Cellular Oncology
|March 20, 2026
PubMed

Insights

The LNK adaptor protein regulates key cancer pathways. Its role in solid tumors is complex, sometimes inhibiting and sometimes activating cancer cell growth and migration.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Signaling

Background:

  • Cancer is characterized by uncontrolled cell proliferation, survival, and migration.
  • Dysregulation of JAK/STAT, MAPK, and PI3K/AKT pathways is common in solid tumors.
  • The LNK adaptor protein normally inhibits these pathways in healthy cells and hematological malignancies.

Purpose of the Study:

  • To review the functions of LNK in healthy tissues.
  • To compare LNK's roles in normal cells versus solid tumors.
  • To explore mechanisms behind LNK's dual functions in cancer.

Main Methods:

  • Literature review of LNK protein function.
  • Comparative analysis of LNK activity in different cancer types.
  • Discussion of potential regulatory mechanisms.

Main Results:

  • LNK acts as a negative regulator in normal cells and some blood cancers.
  • Evidence shows LNK can inhibit proliferation and migration in some solid tumors.
  • Conversely, LNK can activate proliferation and migration in other solid tumors.

Conclusions:

  • LNK exhibits context-dependent roles in solid tumor progression.
  • Understanding LNK's dual functions is crucial for cancer research.
  • Further investigation into LNK mechanisms may reveal therapeutic targets.
Keywords:
JAK/STATLNKmigrationproliferationsolid tumors

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