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Association Between Pulmonary Function, Respiratory Muscle Strength and Cognitive Function in Chinese
Zhichao He1, Guirong Cheng1,2, Shiyue Li3
1Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Clinical Interventions in Aging
|March 20, 2026
Summary
Pulmonary function and respiratory muscle strength are linked to cognitive health in older adults. Maintaining lung and muscle function may help preserve cognitive abilities and reduce impairment risk.
Area of Science:
- Gerontology
- Pulmonology
- Neurology
Background:
- Pulmonary function (PF) and respiratory muscle strength (RMS) decline with age.
- The relationship between PF, RMS, and cognitive outcomes is not fully understood.
- Environmental and genetic factors influence PF and RMS, with inconsistent links to cognition.
Purpose of the Study:
- To investigate associations between PF, RMS, and cognitive function in Chinese community-dwelling older adults.
- To analyze interactions with APOE Ɛ4 genotype.
- To explore the mediating effect of serum total bilirubin on these relationships.
Main Methods:
- 1,081 participants from the Hubei Memory and Aging Cohort (HMACS) underwent assessments.
- Evaluated PF (PEF, FEV1, FVC) and RMS (MIP, MEP).
- Used multivariate logistic and general linear regression analyses.
Main Results:
- Lower PF and RMS scores were associated with cognitive impairment (26.1% prevalence).
- Higher PF and RMS indices showed protective effects against cognitive impairment.
- PF and RMS indices positively correlated with global cognition, memory, language, and executive function, with sex-specific differences observed.
Conclusions:
- Pulmonary function (PEF) and respiratory muscle strength (MEP) are significantly associated with cognitive function and impairment in older adults.
- These associations are independent of APOE Ɛ4 status.
- Findings suggest PF and RMS as potential biomarkers for cognitive health and targets for interventions.
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