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Updated: Jun 20, 2026
07:12
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
Genetically Causal Associations Between Adenomyosis/Endometriosis and Adverse Pregnancy Outcomes - A Two-Sample
Jingyun Wang1, Lu Wang1, Xiaohui Wang1
1Department of Reproductive Medicine, Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
International Journal of Women'S Health
|March 20, 2026
Summary
Endometriosis may increase the risk of multiple consecutive miscarriages. This study used Mendelian randomization to investigate the link between endometriosis, adenomyosis, and adverse pregnancy outcomes.
Area of Science:
- Reproductive Medicine
- Genetics
- Epidemiology
Background:
- Observational studies suggest a link between adenomyosis/endometriosis and adverse pregnancy outcomes (APOs).
- The precise relationship between these conditions and pregnancy complications remains unclear.
- Further investigation is needed to establish causality.
Purpose of the Study:
- To investigate the potential causal relationship between genetically predicted adenomyosis/endometriosis and APOs.
- To assess the influence of endometriosis and adenomyosis on outcomes such as miscarriage, preterm birth, and birth weight.
- To utilize Mendelian randomization (MR) for robust causal inference.
Main Methods:
- Two-sample Mendelian randomization (MR) analysis using genome-wide association study (GWAS) summary statistics.
- Inverse-variance weighted (IVW) method as the primary analysis.
- Sensitivity analyses including weighted median, MR Egger regression, MR-PRESSO, and leave-one-out analysis to assess robustness and pleiotropy.
Main Results:
- Endometriosis was associated with an increased risk of multiple consecutive miscarriage (OR = 1.07, P = 0.05).
- No significant associations were found between adenomyosis and preterm birth, birth weight, or other APOs.
- Sensitivity analyses supported the robustness of the findings, with no significant horizontal pleiotropy detected by MR-Egger regression.
Conclusions:
- This study provides evidence suggesting endometriosis as a potential risk factor for multiple consecutive miscarriages.
- The findings highlight the importance of considering endometriosis in pregnancy planning and management.
- Further research may explore mechanisms linking endometriosis to miscarriage.
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