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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Sex-Based Differences in Outcomes Following Mitral Valve Surgery: A Contemporary Analysis From 2 Institutions.
Boateng Kubi1, Thais Faggion Vinholo2, Selena Li1
1Division of Cardiac Surgery Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Journal of the American Heart Association
|March 20, 2026
Summary
Sex is not an independent risk factor for operative mortality after mitral valve surgery. This study found no significant difference in mortality rates between men and women undergoing this procedure.
Area of Science:
- Cardiovascular Surgery
- Surgical Outcomes
- Sex Differences in Medicine
Background:
- Investigating sex as an independent risk factor for perioperative mortality after mitral valve surgery is crucial due to differing operative characteristics.
- Previous studies have not definitively established the role of sex in outcomes following mitral valve surgery.
Purpose of the Study:
- To determine if female sex is an independent predictor of operative mortality in patients undergoing mitral valve surgery.
- To analyze the impact of sex on perioperative outcomes and mortality in a large cohort.
Main Methods:
- Retrospective cohort study of 3313 adult patients undergoing mitral valve surgery (2011-2024).
- Patients stratified by sex; primary outcome was operative mortality.
- Multivariable logistic regression analysis to identify independent predictors of mortality.
Main Results:
- Women were older, had higher rates of advanced heart failure, and were less likely to undergo mitral valve repair.
- Despite longer intensive care unit stays for women, operative mortality rates did not differ significantly between sexes (1.42% vs. 0.92%, P=0.32).
- Female sex was not significantly associated with mortality after adjusting for clinical and operative factors (OR, 1.03; P=0.66).
Conclusions:
- Operative mortality after mitral valve surgery is not significantly influenced by sex.
- Differences in baseline characteristics and surgical approaches do not translate to sex-based differences in mortality.
- Female sex is not an independent risk factor for operative mortality in elective mitral valve surgery.
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