Multiple Mononeuropathy Secondary to Parvovirus B19 Infection: A Case Series.

Area of Science:

• Neurology
• Infectious Diseases
• Immunology

Background:

• Parvovirus B19 (B19V) infection is a known cause of neurological complications.
• Multiple mononeuropathy (MM) is a rare neurological manifestation of B19V infection.

Purpose of the Study:

• To characterize the clinical, electrophysiological, and prognostic features of B19V-related MM.
• To improve understanding of this rare neurological complication.

Main Methods:

• Retrospective, observational, multicenter study.
• Inclusion of patients diagnosed with B19V-related MM between 2015 and 2025.
• Data collection from seven university hospitals in France and Switzerland.

Main Results:

• Twenty-one immunocompetent patients were included, with a median age of 40 years.
• Predominant symptoms included sensory deficits (100%), neuropathic pain (90%), motor weakness (43%), and cranial nerve involvement (33%).
• B19V DNA was detected in blood (95%) and nerves (100% of tested).

Conclusions:

• B19V infection should be systematically investigated in patients with MM.
• Particular attention should be given to young individuals with sensory symptoms, upper limb nerve involvement, or cranial nerve involvement.
• Most patients experienced partial recovery after immunomodulatory treatment.