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Updated: Mar 21, 2026

Live Imaging of Microtubule Dynamics in Glioblastoma Cells Invading the Zebrafish Brain
Published on: July 29, 2022
[When organelle positioning drives tumor progression]
Katerina Jerabkova-Roda1, Vincent Hyenne2, Jacky G Goetz1
1Tumor Biomechanics Lab, Inserm UMRS1109, Strasbourg, France - Université de Strasbourg, Strasbourg, France - Fédération de médecine translationnelle de Strasbourg (FMTS), Strasbourg, France - Équipe labellisée Ligue contre le cancer.
Abstract:
Long considered mere degradative compartments, lysosomes are now recognized as key regulators of metabolism, signaling, and tumor invasion. Here, we discuss how their intracellular localization controls their function, signaling, and secretion. In melanoma, the peripheral distribution of lysosomes promotes aggressiveness and metastasis. Similar changes exist in other types of cancer, highlighting the role of lysosomal trafficking as a factor in malignancy and as a promising biomarker for diagnosis and treatment.
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