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Updated: Jul 9, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
[In vivo CAR-Ts, a significant breakthrough]
1Biologiste, généticien, Président d'Aprogène (association pour la promotion de la génomique), Marseille, France.
Abstract:
Since 2017, the CAR-T ex vivo approach has been very successful for the treatment of B cell malignancies in spite of its complexity and cost. A novel method involves transforming T lymphocytes into CAR-T cells in situ (therefore, in vivo) and promises simplicity, speed and affordability. It also seems applicable to several autoimmune diseases and is currently the object of much activity and interest in academic and corporate environments.
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