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Updated: Mar 21, 2026

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Biocompatible Lubricant-Coated Flexible Neural Probes with Enhanced Long-Term Recording Stability.

Haeyun Lee1, Seungjun Lee1,2, Kyeong Seob Hwang3

  • 1School of Electronic and Electrical Engineering, Kyungpook National University, Daegu 41566, Republic of Korea.

ACS Applied Bio Materials
|March 20, 2026
PubMed
Summary

Flexible neural probes using a biocompatible lubricant coating reduce brain inflammation and improve long-term recording stability for brain-machine interfaces (BMIs). This scalable manufacturing approach enhances device performance and minimizes tissue damage.

Keywords:
chronic electrophysiologyflexible printed circuit board (FPCB)inflammatory responselubricant coatingneural interfaceneural probe

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Area of Science:

  • Neuroscience
  • Biomaterials Engineering
  • Medical Devices

Background:

  • Implantable neural probes are crucial for brain research and brain-machine interfaces (BMIs).
  • Conventional probes cause inflammation and instability due to mechanical mismatch with brain tissue.

Purpose of the Study:

  • To develop a flexible neural probe with enhanced biocompatibility and long-term stability.
  • To mitigate neuroinflammation and improve recording performance using a novel coating and manufacturing process.

Main Methods:

  • Fabrication of flexible neural probes using commercial flexible printed circuit board (FPCB) processes.
  • Functionalization of probes with a biocompatible lubricant coating to reduce friction and water ingress.
  • Chronic implantation in mouse hippocampi for long-term recording and immunohistochemical analysis (GFAP/Iba1).
  • In vitro cell viability assays to assess biocompatibility.

Main Results:

  • Lubricant-coated probes maintained consistent neural signal quality for weeks in chronic implants.
  • Significantly reduced astrocytic and microglial activation (neuroinflammation) compared to uncoated probes.
  • In vitro assays confirmed high biocompatibility of the coated devices.
  • Demonstrated scalable and cost-effective FPCB manufacturing for flexible neural interfaces.

Conclusions:

  • The flexible, coated neural probes offer a durable, minimally invasive solution for stable, long-term neural recordings.
  • This approach effectively mitigates neuroinflammation and mechanical mismatch, improving device performance.
  • The scalable manufacturing enables practical, next-generation neural interfaces for BMI, deep brain stimulation, and disease modeling.