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Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

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Updated: Jun 3, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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A Nanochiral Biosensor Enables Clinical Anesthesia Monitoring.

Jing Lin1,2, Rui Li3, Xueru Guo1,2

  • 1Department of Anesthesiology and Pain Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Advanced Materials (Deerfield Beach, Fla.)
|March 20, 2026
PubMed
Summary
This summary is machine-generated.

A novel chiral plasma biosensor offers real-time anesthesia monitoring during surgery. This device precisely detects anesthetic concentrations within minutes, improving patient safety and enabling personalized anesthesia management.

Keywords:
chiral biosensorclinical precision anesthesiapoint‐of‐care health monitoring

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Surgical Technology

Background:

  • Inadequate anesthesia monitoring affects millions of patients annually, leading to intraoperative risks.
  • Current methods lack on-site, real-time analysis of anesthetic concentrations during surgery.

Purpose of the Study:

  • To develop a novel biosensor for seamless, timely, and precise on-site analysis of anesthesia concentration.
  • To enable real-time depth of anesthesia monitoring during surgical procedures.

Main Methods:

  • Integration of a 3D nano-helical silver array with an optofluidic chip for a chiral plasma biosensor.
  • Utilizing capillary-driven flow for rapid plasma separation and surface-enhanced Raman scattering (SERS) for anesthetic detection.
  • Clinical application for monitoring anesthetics and determining individual drug metabolism profiles.

Main Results:

  • The biosensor achieves a detection limit of 0.1 µg/mL for anesthetics.
  • Analysis is completed within one minute, significantly improving temporal resolution compared to existing methods.
  • Demonstrated successful clinical application for personalized anesthesia management.

Conclusions:

  • The developed chiral plasma biosensor provides precise, on-site, real-time anesthesia monitoring.
  • This technology addresses critical clinical needs for improved patient safety and personalized anesthesia.
  • The user-friendly diagnostic system with mobile applications facilitates widespread clinical adoption.