Related Experiment Video
Updated: Mar 22, 2026

3D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells
Published on: October 17, 2025
Precision modulation of the gut microbiota-immune axis by natural products: a structure-activity relationship
Yu-Chen Liu1, Bing Liu2,3, Ting Zhu2,3
1Postdoctoral Station on Chinese Materia Medica of Harbin University of Commerce, Harbin 150000, China.
Abstract:
Natural products (NPs) provide a chemically precise strategy to overcome gut dysbiosis-driven resistance in cancer immunotherapy. This review deconstructs how distinct structural determinants of polysaccharides, terpenoids, polyphenols, and alkaloids dictate specific microbial remodeling and immunomodulatory outcomes. These structure-activity relationship (SAR)-driven mechanisms selectively enrich beneficial microbes, modulate metabolites, and reprogram host immune pathways, thereby potentiating diverse immunotherapies and converting "cold" tumors into "hot" ones. Future integration of SAR with AI-driven multi-omics and synthetic biology will enable rational design of next-generation NPs and personalized interventions, offering a promising avenue for more effective and less toxic cancer immunotherapies.
More Related Videos
08:42Establishment of a Co-culture System of Patient-Derived Colorectal Tumor Organoids and Tumor-Infiltrating Lymphocytes (TILs)
Published on: June 27, 2025
06:07Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
Published on: June 13, 2020
Related Concept Videos
Tumor Immunotherapy
Microorganisms in Medicine and Therapeutics
Functions of the Gut Microbiota
Drugs that Stabilize Microtubules
Probiotics
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...