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Updated: Mar 22, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Visible-Light-Enabled Sulfonyl Radical-Triggered Cyclization Strategy for the Efficient Synthesis of Benzosultams
Mithu Roy1, Sanatjit Kar1, Masthan Thamim1
1Department of Chemistry, Indian Institute of Technology-Guwahati, Kamrup, Assam 781039, India.
None:
We introduce a green and practical visible-light-driven method to synthesize benzosultam derivatives using an eosin Y organophotocatalyst. Under ambient conditions, N-alkyl-N-propargyl arylsulfonamides react with sodium aryl sulfinates through a sulfonyl-radical-driven cyclization to produce the corresponding exocyclic benzosultams. Furthermore, these products smoothly isomerize to their endocyclic forms with a mild base. This metal-free approach is mild, versatile, and eco-friendly, providing excellent yields over a wide range of substrates.
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