Palladium Catalyzed Asymmetric C(sp)-P Cross-Coupling via Kinetic Resolution of Secondary Phosphine Oxides
Jianguo Gu1, Yuting Wu1, Zhongkuan Tang1
1Department of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing 210094, China.
Abstract:
Herein, we report a palladium-catalyzed asymmetric C(sp)-P cross-coupling reaction between secondary phosphine oxides (SPOs) and alkynyl chlorides, providing a direct and efficient route to access P-stereogenic alkynyl phosphine oxides via a kinetic resolution process. This method proceeds under mild conditions, delivering products with excellent enantioselectivity (up to 94% ee) and good functional group tolerance. This work offers a straightforward and modular strategy for the synthesis of valuable chiral alkynyl phosphorus compounds.
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