Gender differences in the association between TyG-related index, metabolic score for insulin resistance, and...

The triglyceride-glucose (TyG) index and the metabolic score for insulin resistance (METS-IR) are emerging indicators of IR. This study aimed to explore the correlation between these emerging IR indicators and overactive bladder (OAB) in the US population. This study utilized data from a total of 12,638 participants in the 2007 to 2018 National Health and Nutrition Examination Survey. OAB symptoms were assessed using the Overactive Bladder Symptom Score, and IR was evaluated using the TyG-body mass index, TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference, and METS-IR indices. To analyze the data, the study methods included multivariable logistic regression, subgroup analysis, restricted cubic spline curve analysis, and receiver operating characteristic curve analysis. A total of 3032 participants were diagnosed with OAB, with women accounting for approximately 67.41% of the cases. The indices TyG-body mass index, TyG-WHtR, TyG-waist circumference, and METS-IR were positively associated with OAB, with odds ratios of 1.28 (per z-score, 95% confidence interval [CI]: 1.22, 1.34), 1.30 (per z-score, 95% CI: 1.23, 1.37), 1.28 (per z-score, 95% CI: 1.22, 1.35), and 1.13 (per z-score, 95% CI: 1.07, 1.19), respectively. Furthermore, restricted cubic spline analysis indicated a nonlinear connection between TyG-WHtR and OAB, with a turning point at 3.834. Subgroup analysis further showed a stronger association among younger and middle-aged women aged 20 to 50 years. Receiver operating characteristic analysis demonstrated that TyG-WHtR had the highest area under the curve (0.642). Sensitivity analysis demonstrates the robustness of our results. This study demonstrates that the TyG-related indices and METS-IR are positively associated with OAB in the US population, particularly among younger women. Among the evaluated indices, TyG-WHtR showed the strongest diagnostic performance for OAB.