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Updated: Mar 22, 2026

A Simple and Efficient Protocol for the Catalytic Insertion Polymerization of Functional Norbornenes
Published on: February 27, 2017
Palladium-Catalyzed Annulation of Acyl Saccharins with Norbornene via CO Shuttling
Avinash D Rokade1, Nikhil M Teke1, Kishor L Handore1,2
1Organic Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
Abstract:
Palladium-catalyzed annulation presents a new approach for synthesizing indanones from readily available N-acyl saccharins and bicyclic alkenes with high yields. This reaction proceeds via cleavage of the C-H, C-C, and C-N bonds of the acyl saccharin and the rearrangement of the carbonyl moiety by decarbonylation and CO reinsertion. This transformation introduces an innovative bond disconnection strategy for annulation reactions via CO shuttling. Additionally, it can also be applied in the synthesis of the CDC7 inhibitor and ferrocene indanone.
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