Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population.

Clinica chimica acta; international journal of clinical chemistry·2010

Same author

Three-component assembly and divergent ring-expansion cascades of functionalized 2-iminooxetanes.

Angewandte Chemie (International ed. in English)·2010

Same author

Prokaryotic expression and potential application of the truncated PCV-2 capsid protein.

Virologica Sinica·2010

Same author

Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus.

The Journal of rheumatology·2010

Same author

Peptide dendrimers as efficient and biocompatible gene delivery vectors: Synthesis and in vitro characterization.

Journal of controlled release : official journal of the Controlled Release Society·2010

Same author

The amplification and evolution of orthologous 22-kDa α-prolamin tandemly arrayed genes in coix, sorghum and maize genomes.

Plant molecular biology·2010

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Published on: August 16, 2014

High performance injectable PLLA/BG composite microspheres in aging skin regeneration.

Zi Lin Li¹, Gang Wang², Yilin Ding³

¹School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China; National Engineering Research Centre for Tissue Restoration and Reconstruction, Guangzhou, 510006, PR China; Medical Devices Research & Testing Center, South China University of Technology, Guangzhou, 510006, PR China.

Biomaterials Advances

|March 20, 2026

Summary

Novel Poly-L-lactic acid (PLLA) composite microspheres with bioactive glass (BG) enhance skin regeneration. These PLLA/BG microspheres improve fibroblast behavior, boost extracellular matrix production, and promote tissue repair for anti-aging applications.

More Related Videos

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation

Published on: April 5, 2024

Related Experiment Videos

Last Updated: Mar 22, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

Published on: August 16, 2014

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology

Published on: May 16, 2022

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation

Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation

Published on: April 5, 2024

Area of Science:

Biomaterials Science
Tissue Engineering
Dermatology

Background:

Poly-L-lactic acid (PLLA) microspheres are used for skin rejuvenation but can cause inflammation due to hydrophobicity and acidic degradation products.
Biodegradable polymers integrated with bioactive components offer potential for improved biocompatibility and active tissue regeneration.

Purpose of the Study:

To engineer novel Poly-L-lactic acid (PLLA) and bioactive glass (BG) composite microspheres.
To evaluate the in vitro and in vivo efficacy of PLLA/BG composite microspheres in promoting skin regeneration and rejuvenation.

Main Methods:

Fabrication of PLLA/BG composite microspheres.
In vitro assessment of human foreskin fibroblast (HFF) behavior, extracellular matrix (ECM) protein expression, and macrophage polarization.
In vivo evaluation in a wrinkle-induced mouse model, assessing wrinkle formation, ECM deposition, and angiogenesis.

Main Results:

PLLA/BG microspheres significantly enhanced HFF biological behaviors and upregulated critical ECM proteins.
The microspheres promoted a pro-regenerative response by increasing transforming growth factor β1 (TGF-β1) and PDZ and LIM domain 5 (PDLIM5) expression.
In vivo studies showed PLLA/BG microspheres suppressed wrinkles, increased ECM deposition, and stimulated new blood vessel formation.

Conclusions:

PLLA/BG composite microspheres demonstrate potent biomimetic properties, enhancing cellular activities and tissue repair.
These novel microspheres effectively modulate the skin microenvironment, offering a promising strategy for rejuvenating aging skin.
The integration of BG into PLLA microspheres overcomes inherent material limitations, leading to improved biocompatibility and regenerative potential.