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TimeVault: A molecular time machine for single cells
1Center for Spatial Omics, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Cellular and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA; Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN, USA.
None:
In a recent issue of Science, Chao et al.1 describe TimeVault, an approach that allows researchers to reconstruct past transcriptional states even as cells continue to divide and differentiate. It provides an alternative to conventional single-cell RNA sequencing (scRNA-seq), which captures only a terminal "snapshot," by preserving molecular history within intact cells.
