Related Experiment Video
Updated: Mar 22, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
7 for 11: Updates in pediatric anaphylaxis
Catherine Ye1, Stephanie Jeong1, Julie Wang1
1Department of Allergy/Immunology, Icahn School of Medicine at Mount Sinai, New York City, New York.
A new consensus definition and updated management strategies for pediatric anaphylaxis (a severe allergic reaction) have been released. These advances aim to improve recognition and care for children experiencing anaphylaxis.
Area of Science:
- Pediatric Allergy and Immunology
- Emergency Medicine
- Public Health
Background:
- Lack of a standardized definition and clinical tools has historically hindered anaphylaxis diagnosis and management.
- Pediatric anaphylaxis requires specific considerations due to evolving definitions and management protocols.
Purpose of the Study:
- To review recent advancements in pediatric anaphylaxis recognition and management.
- To highlight the impact of a new international consensus definition and updated clinical tools.
- To discuss changes in the management of pediatric anaphylaxis.
Main Methods:
- Review of recent literature and expert panel publications on pediatric anaphylaxis.
- Analysis of newly introduced clinical tools and management guidelines.
- Examination of updated recommendations for allergy action plans and epinephrine administration.
Main Results:
- A new international consensus definition and clinical tool for anaphylaxis were published in 2025.
- Introduction of intranasal epinephrine and revised allergy action plans with age-specific symptom descriptions.
- Emphasis on shared decision-making, accessibility, and increased primary care provider involvement in school settings.
Conclusions:
- Ongoing challenges exist in integrating evolving anaphylaxis definitions and refinements into clinical practice.
- Accessible and reliable tools are crucial for healthcare providers and patients to recognize and manage anaphylaxis effectively.
- Continued efforts are needed to integrate validated clinical support tools and standardized action plans into real-world care settings.
Related Concept Videos
Allergic Reactions: Anaphylaxis
Allergic Reactions
Allergic Drug Reactions
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Drug Dosing: Infants and Children

