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Related Concept Videos

Relative Risk01:12

Relative Risk

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Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
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Methods of reducing fever01:22

Methods of reducing fever

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Related Experiment Video

Updated: Mar 22, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Test Characteristics of C-Reactive Protein-Based Risk Stratification in Young, Well-Appearing, Febrile Infants.

Lyubina C Yankova1, Corrie E McDaniel2, Ellen Kerns3

  • 1Section of Pediatric Hospital Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, CT.

The Journal of Pediatrics
|March 20, 2026
PubMed
Summary

C-reactive protein and procalcitonin effectively identify invasive bacterial infections in febrile infants. This combination shows high sensitivity for detecting serious infections in newborns and young infants.

Keywords:
infant sepsisinflammatory markersprocalcitonin

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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Febrile infants require accurate diagnostic tools to differentiate serious bacterial infections from benign conditions.
  • Inflammatory markers are crucial in assessing infection risk in neonates and young infants.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of C-reactive protein (CRP) and other inflammatory markers (IMs) for invasive bacterial infection (IBI).
  • To assess the combined performance of CRP with other IMs in well-appearing, febrile infants aged 8-60 days.

Main Methods:

  • Retrospective cohort study design.
  • Analysis of test characteristics for CRP alone and in combination with other IMs.
  • Focus on well-appearing, febrile infants aged 8-60 days.

Main Results:

  • The combination of procalcitonin and CRP showed a sensitivity of 91.4% (95% CI: 84.7-95.8).
  • The combined procalcitonin and CRP also demonstrated a specificity of 76.5% (95% CI: 75.3-77.6).

Conclusions:

  • Combined procalcitonin and CRP offer valuable diagnostic information for IBI in febrile infants.
  • This biomarker combination aids in the clinical decision-making process for managing infection in young infants.