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Bidirectional association between chronic periodontitis and bronchiectasis: A nationwide, population-based cohort
Sungmin Zo1, Min Ji Kim2, Min Gu Kang2
1Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Background:
This study investigated the potential bidirectional association between chronic periodontitis (CP) and bronchiectasis using the Korean National Health Insurance Service claims database.
Methods:
In study I, individuals with CP (n = 54,535) were matched to those without CP, and in study II, individuals with bronchiectasis (n = 2804) were matched to those without bronchiectasis, using 1:1 propensity score matching. Individuals were followed until the date of bronchiectasis diagnosis (study I), the date of CP diagnosis (study II), death, or December 31, 2019, whichever came first.
Results:
In study I, during a median follow-up of 11.8 years, 4.25% of the CP group and 0.77% of the control group developed bronchiectasis. The risk of developing bronchiectasis was significantly higher in the CP group compared to the matched controls (hazard ratio [HR] 3.35; 95% confidence interval [CI] 3.02-3.73). In study II, the risk of CP was also higher in the bronchiectasis group compared with matched controls (HR 1.07; 95% CI 1.01-1.15).
Conclusion:
CP and bronchiectasis were bidirectionally associated, although CP had a stronger impact on bronchiectasis risk than the reverse association.
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