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Both the PANSS cognitive component and MATRICS consensus cognitive domains are linked to functional outcome in
Chieh-Hsin Lin1, Shaw-Ji Chen2, Tin-May Li3
1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Background:
The Positive and Negative Syndrome Scale (PANSS) has been widely used as a clinical assessment for schizophrenia. The cognitive component of the PANSS (PANSS cog) as well as cognitive tests, including 7 MATRICS consensus cognitive domains, have been employed for measuring cognitive function; however, their differential associations with functional outcome in the patients with schizophrenia remain unclear.
Methods:
We at first examined the relationship between PANSS cog and each of 7 MATRICS cognitive domains in 380 Taiwanese schizophrenia patients, and then the influences of PANSS cog and 7 cognitive domains on their functional outcome, measured by the Global Assessment of Functioning (GAF) scale and the Quality of Life (QoL) scale.
Results:
PANSS cog scores were negatively and significantly correlated with scores of all cognitive domains (all p values <0.001), with social cognition having the smallest correlation (r = -0.28) and other domains having better correlations (r = -0.43 [verbal learning and memory] - -0.65 [speed of processing]). Multiple linear regression showed that PANSS-cog, speed of processing, and verbal learning were linked to both GAF and QoL. Besides, problem solving was associated with GAF; and social cognition, with QoL.
Conclusion:
The findings of the study suggest that PANSS cog is connected to every MATRICS cognitive domain (social cognition being the least) and PANSS cog as well as certain cognitive domains are linked to functional outcome. Further longitudinal studies in other populations are warranted.
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