Related Experiment Video

Updated: Mar 22, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

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FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression

Jianhua Qin1, Shuang Ma1, Junyang Wang1

  • 1The HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

Cell Death & Disease
|March 21, 2026
PubMed
Summary

Defactinib inhibits FAK/SRC-JNK signaling, suppressing ferroptosis by modulating ACSL4 expression. This pathway impacts cancer therapy and acute pancreatitis, offering new therapeutic targets.

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