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Liver Histiocytosis Masquerading as Hepatic Dysfunction: Rare Case Story
Emilija Nikolovska Trpchevska1,2, Meri Trajkovska1,2, Dafina Nikolova1,2
11University Clinic for Gastroenterohepatology, "Ss. Cyril and Methodius" University in Skopje, North Macedonia.
Summary
Langerhans cell histiocytosis (LCH) is a rare liver disease in adults. This case highlights the diagnostic challenges of LCH presenting as isolated liver injury in adults.
Area of Science:
- Oncology
- Hepatology
- Pathology
Background:
- Langerhans cell histiocytosis (LCH) is a rare neoplastic proliferation of Langerhans cells.
- LCH predominantly affects children, with adult cases being infrequent.
- Liver involvement in adult LCH is uncommon and presents a diagnostic challenge.
Purpose of the Study:
- To report a rare case of adult Langerhans cell histiocytosis with liver involvement.
- To discuss the diagnostic difficulties and clinical presentation of LCH in the liver.
- To emphasize the importance of considering LCH in the differential diagnosis of adult liver disease.
Main Methods:
- Case presentation of a 40-year-old male with painless jaundice and abnormal liver function tests.
- Diagnostic work-up including imaging (hepatosplenomegaly) and exclusion of common liver pathologies.
- Liver biopsy with histopathological examination and immunohistochemical staining.
Main Results:
- The patient presented with symptoms suggestive of liver dysfunction.
- Liver biopsy confirmed the diagnosis of Langerhans cell histiocytosis.
- Hepatoprotective therapy led to symptom improvement and normalized liver function.
Conclusions:
- Isolated LCH-related liver injury is a rare clinical entity in adults.
- Distinguishing LCH from other liver pathologies can be challenging for clinicians and radiologists.
- Early diagnosis and appropriate management are crucial for favorable outcomes in adult LCH with liver involvement.
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