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Related Experiment Video

Updated: Mar 22, 2026

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
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Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

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Shengmai Yin Alleviates Particulate Matter-Aggravated Ischemic Damage by Inhibiting S100a9 Expression.

Yuan-Min Yang1,2, Yu Zhang1,3, Yu Li1

  • 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.

Environmental Toxicology
|March 21, 2026
PubMed
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Air pollution worsens heart injury by increasing S100a9, a protein found in neutrophils. Shengmai Yin, a traditional remedy, reduces this protein and protects against pollution-induced heart damage.

Area of Science:

  • Environmental Health
  • Cardiovascular Biology
  • Immunology

Background:

  • Air pollution, specifically particulate matter (PM), exacerbates ischemic cardiomyopathy and impairs healing.
  • Traditional Chinese medicine, Shengmai Yin, is used for coronary heart disease.
  • Identifying molecular mechanisms linking PM exposure to myocardial injury is crucial.

Purpose of the Study:

  • To investigate the molecular mechanisms by which PM exposure aggravates myocardial ischemic injury.
  • To identify key genes and proteins involved in PM-induced exacerbation of heart injury.
  • To evaluate the therapeutic potential of Shengmai Yin in mitigating PM-aggravated myocardial ischemia.

Main Methods:

  • Transcriptome and proteome analyses to identify associated genes.
Keywords:
S100a9Shengmai yinmyocardial ischemicparticulate matter

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Last Updated: Mar 22, 2026

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  • Construction of a mouse model of myocardial ischemia exacerbated by PM exposure.
  • Measurement of gene/protein expression, inflammatory markers, and neutrophil infiltration.
  • Immunofluorescence staining to determine the origin of S100a9.
  • Assessment of Shengmai Yin's effects on myocardial injury and inflammation.

    • Main Results:

    • PM exposure significantly upregulated S100a8 and S100a9, increased myocardial injury, IL-6, Ccl2 levels, and neutrophil infiltration.
    • S100a9 was identified as a key molecule involved in PM-aggravated myocardial ischemic injury, originating from neutrophils.
    • Shengmai Yin administration significantly alleviated myocardial injury, reduced inflammatory factors (IL-1β, IL-6), and decreased neutrophil infiltration.

    Conclusions:

    • S100a9 plays a critical role in the exacerbation of myocardial ischemic injury by PM exposure.
    • Shengmai Yin demonstrates therapeutic efficacy against PM-aggravated myocardial ischemic injury by downregulating S100a9.
    • Targeting S100a9 presents a potential therapeutic strategy for mitigating air pollution-induced heart damage.