Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

10.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
10.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circumferential Subclavian Artery Dissection in Marfan Syndrome.

Korean circulation journal·2026
Same author

Utility of various positron emission tomography tracers in differentiating primary central nervous system lymphoma from glioblastoma multiforme.

EJNMMI reports·2026
Same author

Head-to-head comparison of <sup>11</sup>C-PiB and <sup>18</sup>F-flutemetamol PET in transthyretin cardiac amyloidosis.

European journal of nuclear medicine and molecular imaging·2026
Same author

Direct comparison uptake patterns of <sup>99m</sup>Tc-PYP and <sup>99m</sup>Tc-HMDP scintigraphy in cardiac amyloidosis with semi-quantitative analysis.

Japanese journal of radiology·2026
Same author

Harmonized quantitative bone SPECT/CT parameters for risk assessment of medication-related osteonecrosis of the jaw: multicenter study.

EJNMMI research·2026
Same author

Multicentre survey of diagnostic reference levels for single-photon emission computed tomography/computed tomography and PET/computed tomography examinations at Japanese National University Hospitals: a comparative international analysis.

Nuclear medicine communications·2026

Related Experiment Video

Updated: Mar 23, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

800

A reference-based approach using whole-brain segmentation for image-derived PET input functions in CBF, OEF, and

Nobuyuki Kudomi1, Yukito Maeda2,3, Takuya Kobata2

  • 1Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|March 21, 2026
PubMed
Summary

This study introduces a noninvasive method using 15O PET to estimate cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) without arterial blood sampling. The image-derived input function (IDIF) method shows high accuracy and clinical feasibility.

Keywords:
CBFCMRO2IDIFOEFPET

More Related Videos

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
05:23

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

933
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K

Related Experiment Videos

Last Updated: Mar 23, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

800
Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
05:23

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

933
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K

Area of Science:

  • Neuroimaging
  • Nuclear Medicine
  • Cerebrovascular Physiology

Background:

  • Quantitative measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) using 15O-labeled PET typically require invasive arterial input function (AIF) measurements.
  • Arterial blood sampling poses risks and logistical challenges in clinical settings.

Purpose of the Study:

  • To develop and validate a fully noninvasive method for reconstructing an image-derived input function (IDIF) directly from dynamic 15O2-H215O PET data.
  • To enable accurate, noninvasive quantification of CBF, OEF, and CMRO2.

Main Methods:

  • A reference-based approach was used with data from 186 subjects with suspected cerebrovascular disease.
  • Segment-based reference values from 60 subjects were applied to reconstruct IDIFs in 126 subjects.
  • IDIFs were reconstructed using coefficient-of-variation weighted averaging of segmental tissue time-activity curves.

Main Results:

  • Estimated IDIFs demonstrated strong agreement with measured AIFs.
  • High correlations (r=0.88, p<0.001) and minimal bias (≤0.005) were observed for CBF, OEF, and CMRO2.
  • No significant differences were found between IDIF- and AIF-based quantitative values, although mild regression-to-the-mean was noted in IDIFs.

Conclusions:

  • The proposed method reliably estimates input functions from tissue curves without the need for blood sampling.
  • This enables fully noninvasive quantification of CBF, OEF, and CMRO2 using 15O PET.
  • The method is clinically feasible for standard 15O PET studies but not for quantitative parameter estimation under stimulation.