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Related Concept Videos

Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
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Coagulation-Independent Hemostasis Through Architecturally Programmed Chitosan Aerogels with Dual-Crosslinked

Yujia Fang1, Lanxin Mu1, Yiwen Lu1

  • 1College of Chemistry & Molecular Sciences, Institute of Hepatobiliary Diseases, Transplant Center, Zhongnan Hospital, Hubei Engineering Centre of Natural Polymers-based Medical Materials, Wuhan University, Wuhan, China.

Advanced Materials (Deerfield Beach, Fla.)
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Summary

New dual-crosslinked chitosan aerogels offer rapid, coagulation-independent hemostasis. This advanced material effectively controls bleeding in emergency medicine and surgery, even with anticoagulation, by physically occluding wounds.

Keywords:
aerogelschitosancoagulation‐independent hemostasisdual‐crosslinkinghierarchical architecture

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Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Emergency Medicine

Background:

  • Hemorrhage control is critical in emergency medicine and surgery.
  • Existing hemostats often fail in cases of anticoagulation or coagulopathy.
  • There is a need for effective hemostatic agents that bypass the coagulation cascade.

Purpose of the Study:

  • To develop a novel hemostatic material for effective bleeding control.
  • To investigate a coagulation-independent hemostasis mechanism.
  • To evaluate the efficacy of dual-crosslinked ultra-highly deacetylated chitosan (DC-UDCS) aerogels in hemorrhage control.

Main Methods:

  • Fabrication of hierarchically structured, dual-crosslinked DC-UDCS aerogels using directional ice-templating.
  • Investigation of the dual-crosslinked hierarchical capillary-elastic memory (DC-HCEM) mechanism.
  • In vitro and in vivo testing in normal and anticoagulated hemorrhage models.

Main Results:

  • DC-UDCS aerogels demonstrated rapid capillary infiltration and blood-triggered self-expansion.
  • The material achieved effective hemostasis via physical occlusion and electrostatic erythrocyte aggregation.
  • Successful bleeding control was achieved in both normal and anticoagulated conditions, outperforming conventional gauze.

Conclusions:

  • The developed DC-UDCS aerogel platform offers a promising strategy for lifesaving hemostasis.
  • This approach is effective even when coagulation is compromised.
  • The material exhibits hemocompatibility, biocompatibility, and antibacterial activity.