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Chronic Obstructive Pulmonary Disease and Cardiovascular Disorders
Antonis S Manolis1,2, Antonis A Manolis3, Theodora A Manolis4
1Athens University School of Medicine, Athens, Greece.
Current Vascular Pharmacology
|March 21, 2026
Summary
Chronic obstructive pulmonary disease (COPD) significantly increases cardiovascular disease (CVD) risk. Routine screening after COPD exacerbations is vital for early detection and management of heart conditions like coronary artery disease.
Area of Science:
- Pulmonary Medicine
- Cardiology
- Public Health
Background:
- Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally, particularly during exacerbations.
- COPD patients frequently have cardiovascular comorbidities, necessitating routine cardiovascular screening.
- COPD and cardiovascular disease (CVD) share risk factors and pathophysiological pathways, including systemic inflammation and atherosclerosis.
Purpose of the Study:
- To highlight the intricate relationship between COPD and CVD.
- To emphasize the underdiagnosis and undertreatment of CVD in COPD patients due to overlapping symptoms.
- To advocate for structured cardiovascular assessment post-COPD exacerbation.
Main Methods:
- Review of existing literature, metaanalyses, and key clinical guidelines.
- Illustration of the interrelated mechanisms linking COPD and CVD.
- Discussion of diagnostic challenges posed by overlapping symptomatology.
Main Results:
- CVD is highly prevalent in COPD patients but often underdiagnosed.
- Atypical symptoms of heart failure and coronary artery disease can mimic COPD exacerbations.
- Systemic inflammation, oxidative stress, and endothelial dysfunction are key linking mechanisms.
Conclusions:
- A structured cardiovascular assessment is crucial following COPD exacerbations.
- Early identification and management of CVD in COPD patients can improve outcomes.
- Addressing the interplay between COPD and CVD is essential for comprehensive patient care.
Keywords:
bronchitiscardiac arrhythmiascardiopulmonary disease.cardiovascular diseasechronic coughchronic obstructive pulmonary diseasecigarette smokingcoronary artery diseasedyspneaemphysemaheart failurehypercapniahypoxemiarespiratory acidosisrespiratory insufficiencyshortness of breathstrokeMore Related Videos
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