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Published on: December 1, 2020
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Mapping the Landscape of Drug Target Identification Based on Activity-Based Protein Profiling: A Bibliometric
Weiqing Qian1, Zhenhui Fu1, Yuyang Su1
1Institute of Clinical Anatomy & Reproductive Medicine, Department of Histology and Embryology Hengyang Medical School, University of South China Hengyang, 421001 Hunan, China.
Endocrine, Metabolic & Immune Disorders Drug Targets
|March 21, 2026
Summary
Activity-Based Protein Profiling (ABPP) research is rapidly growing, focusing on technological innovation and clinical translation. Future work will optimize probe design and integrate AI for drug discovery.
Area of Science:
- Biochemistry and Molecular Biology
- Pharmacology and Drug Discovery
- Bioinformatics and Computational Biology
Background:
- Activity-Based Protein Profiling (ABPP) is a powerful technique for drug target identification.
- The field has seen significant growth, with increasing publications and global contributions.
- Understanding the research landscape is crucial for future advancements.
Purpose of the Study:
- To conduct a bibliometric analysis of global research on Activity-Based Protein Profiling (ABPP).
- To outline current research content, progress, and predict future trends in ABPP.
- To identify key institutions, authors, and publications driving innovation in ABPP.
Main Methods:
- A dual-platform data retrieval strategy was employed.
- Visual analysis was performed using CiteSpace and VOSviewer.
- Bibliometric analysis of 5,326 publications from 2006-2025.
Main Results:
- Global publications show an upward trend, accelerating since 2019.
- The United States and China are leading contributors, with the Chinese Academy of Sciences and Benjamin Cravatt as prominent institutions and authors.
- The Journal of Biological Chemistry is a key publication venue, with "protein" and "expression" as highly frequent keywords.
Conclusions:
- Research emphasizes technological innovation, clinical translation, and interdisciplinary integration (AI, spatial omics).
- Future directions include optimizing probe design, enhancing international collaboration, and advancing clinical applications.
- Key research areas involve developing protein inhibitors, drug repurposing, and validating targets for traditional medicine.
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