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lsaC and Tandem lsaE-lnuB Resistance Genes in Invasive Group A Streptococcus
Emerging Infectious Diseases
|March 21, 2026
Summary
Nine new instances of drug resistance genes were found in invasive Streptococcus pyogenes bacteria. This highlights the need to monitor antimicrobial resistance in this pathogen for effective treatment strategies.
Area of Science:
- Microbiology
- Genetics
- Infectious Diseases
Background:
- Streptococcus pyogenes is a significant human pathogen.
- Antimicrobial resistance is a growing global health concern.
- Understanding resistance mechanisms in S. pyogenes is crucial for treatment.
Purpose of the Study:
- To investigate the emergence of novel antimicrobial resistance genes in invasive Streptococcus pyogenes isolates.
- To identify specific genes conferring resistance to pleuromutilins and clindamycin.
Main Methods:
- Analysis of over 16,500 recently recovered invasive Streptococcus pyogenes isolates.
- Detection of specific genetic elements (lsaC, lsaE-lnuB) associated with drug resistance.
Main Results:
- Nine independent acquisitions of resistance genes (lsaC or lsaE-lnuB) were identified.
- These genes confer resistance to pleuromutilins and clindamycin.
Conclusions:
- The S. pyogenes antimicrobial resistosome is evolving.
- Continued surveillance of antimicrobial resistance in S. pyogenes is essential for guiding clinical treatment decisions.
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