Related Experiment Video
Updated: Mar 23, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Circulating fatty acids and gestational diabetes mellitus: A systematic review and meta-analysis of observational
Sara Shojaei-Zarghani1, Zahra Naziri2, Mohammadsadegh Nasr2
1Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background:
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication. Altered fatty acid (FA) metabolism may contribute to GDM development, yet evidence regarding specific circulating FAs remains inconclusive.
Objective:
This systematic review and meta-analysis compared circulating FA profiles between pregnant women with and without GDM and examined their associations with GDM risk.
Methods:
We searched PubMed, Scopus, and Web of Science for observational studies reported circulating FAs in relation to GDM risk. Pooled standardized mean differences (SMDs) and odds ratios (ORs) were calculated using random-effects models. Subgroup analyses explored heterogeneity sources, and the Newcastle-Ottawa Scale assessed risk of bias (RoB).
Results:
Forty-four studies were included. Meta-analysis of ORs indicated that per one-SD increase, C16:0 was associated with higher GDM odds (OR: 1.20, 95%CI: 1.04, 1.38). Conversely, very-long-chain saturated FAs (C22:0 and C24:0), specific omega-6 FAs (C18:2, C20:2, and C22:4) were associated with lower odds. SMD analysis revealed significantly lower circulating levels of C22:0, C15:0, and C17:0 in women with GDM. Subgroup analyses identified FA form (e.g., free FAs vs. phospholipids) as a significant heterogeneity source for eight FAs, measurement unit (absolute concentration vs. relative percentage) for three FAs, while RoB, study design, and trimester were sources for limited specific FAs.
Conclusions:
GDM is associated with distinct circulating FAs patterns. C16:0 is associated with higher odds of GDM, whereas linoleic acid, very-long-chain Saturated FAs, and selected omega-6 FAs were related to lower odds.
Prospero Registration Code:
CRD42025649380.
More Related Videos
06:27Detecting Establishment of Shared Blood Supply in Parabiotic Mice by Caudal Vein Glucose Injection
Published on: February 6, 2020
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Symptoms, Diagnosis, and Complications
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...