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Biomarkers in Traumatic Lung Injury - A Systematic Review.
Eric Forsheden Åhs1, Mattias Günther2
1Department of Surgery, Karolinska University Hospital, Stockholm, Sweden.
The Journal of Surgical Research
|March 21, 2026
Summary
Early detection of traumatic lung injury (TLI) is crucial. Biomarkers like CC16 and sRAGE show promise for diagnosing TLI and predicting its severity, improving patient outcomes.
Area of Science:
- Trauma Care
- Pulmonary Medicine
- Biomarker Discovery
Background:
- Traumatic lung injury (TLI) is a major cause of death and disability.
- TLI can progress to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS).
- Identifying early biomarkers can enhance diagnosis, prognosis, and treatment.
Conclusions:
- Biomarkers hold promise for early TLI diagnosis and patient stratification.
- Club cell protein 16 (CC16), soluble receptor for advanced glycation end-products (sRAGE), and angiopoietin 2 are key prognostic biomarkers for TLI severity.
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