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A developmental switch in corticoclaustral signaling.

Tarek Shaker1, Mohammed Almokdad2, Lotte J A M Razenberg3

  • 1Department of Physiology, University of Alberta, Edmonton, AB T6G2H7, Canada; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G2H7, Canada; Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.

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Summary
This summary is machine-generated.

The anterior cingulate cortex (ACC) primarily inhibits the claustrum in adult mice, but excites it during early development. This developmental switch in ACC-claustrum signaling involves parvalbumin interneurons and impacts brain circuit maturation.

Keywords:
GABAclaustrumdevelopmentinterneuronsparvalbuminprefrontal cortextop-down

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Systems Neuroscience

Background:

  • The anterior cingulate cortex (ACC) is crucial for attention, pain, and predictive coding.
  • ACC neurons project to various brain regions, including the claustrum, influencing cortical networks.
  • Previous studies on ACC-claustrum signaling primarily used adult, in vitro models.

Purpose of the Study:

  • To investigate developmental changes in ACC modulation of claustrum neurons.
  • To elucidate the circuit mechanisms of ACC-claustrum communication across early development and adulthood.
  • To understand the role of parvalbumin interneurons in this developmental trajectory.

Main Methods:

  • In vivo electrophysiological recordings in mice.
  • Analysis of excitatory and inhibitory currents in claustrum neurons.
  • Chemogenetic manipulation to suppress parvalbumin interneurons.

Main Results:

  • ACC activation strongly excites inhibitory claustrum neurons, causing feedforward inhibition in adults.
  • This adult inhibitory effect is partly mediated by parvalbumin interneurons.
  • During early development, ACC inputs cause stronger excitation and slower inhibition, with feedforward excitation observed.

Conclusions:

  • A developmental switch occurs in ACC-claustrum signaling from excitation to inhibition around the third postnatal week.
  • This switch correlates with the maturation of claustrum parvalbumin neurons.
  • Adult ACC inhibition of the claustrum may prevent interference with other ACC projections, while early excitation may aid connectivity establishment.