Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stress and Mental Health01:30

Stress and Mental Health

1.1K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
1.1K
Anxiety: Overview01:18

Anxiety: Overview

1.3K
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
1.3K
Stress Prevention and Stress Management Techniques III01:25

Stress Prevention and Stress Management Techniques III

437
Regular exercise and meditation serve as essential tools in managing stress and promoting physical and mental well-being.
The Role of Exercise in Stress Management
Regular physical activity is essential for reducing stress and promoting cardiovascular health. Exercise strengthens the heart, enhances blood flow, keeps blood vessels flexible, and helps lower blood pressure, all of which reduce the body's stress response. Research shows that adults who exercise regularly have nearly half the...
437
Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

1.0K
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
1.0K
Stress Prevention and Stress Management Techniques IV01:26

Stress Prevention and Stress Management Techniques IV

310
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
310
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

927
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
927

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research-Practice Partnership to Implement Physical Activity Maintenance Strategies in Community-based Exercise Programs for Cancer Survivors.

Progress in community health partnerships : research, education, and action·2026
Same author

Participant versus informant reports of changes in social, emotional, and financial functioning after an exercise intervention with older adults: an actor-partner interdependence model analysis.

Frontiers in psychology·2026
Same author

Prosocial behaviors across bipolar and major depressive mood disorders: A preliminary investigation.

Journal of affective disorders·2026
Same author

Cannabidiol at the crossroads: panacea, placebo, or problem?

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

The highs and lows: Cannabis use and positive valence bipolar mood and emotion processes in emerging adults.

Journal of affective disorders·2026
Same author

Quasi-randomization to Cannabinoid Condition in Studies of US Legal Market Cannabis: Characteristics of Accepters Versus Decliners of Condition Assignment.

Prevention science : the official journal of the Society for Prevention Research·2026

Related Experiment Video

Updated: Mar 23, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K

Physical Activity Level Moderates Cannabis-Associated Reductions in Negative Affect in Anxious Individuals.

Jonathon K Lisano1, Luiza Rosa2, Greg Giordano2

  • 1Institute of Cognitive Science, University of Colorado Boulder, Boulder, Colorado.

Clinical Therapeutics
|March 21, 2026
PubMed
Summary
This summary is machine-generated.

Cannabis use may reduce anxiety, but physical activity

Keywords:
AnxietyCBDCannabidiolCannabisTHCΔ-9-tetrahydrocannabinol

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.0K
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 23, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

15.2K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.0K
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Area of Science:

  • Neuroscience
  • Psychology
  • Pharmacology

Background:

  • Cannabis products, especially those high in cannabidiol (CBD), show anxiolytic potential.
  • Physical activity is also recognized for its anxiety-reducing effects.
  • Limited research exists on the combined effects of physical activity and cannabis on negative affect.

Purpose of the Study:

  • To investigate the synergistic effects of physical activity and cannabis use on reducing negative affect.
  • To examine how different cannabis chemovars (CBD-dominant, THC-dominant, THC+CBD) interact with physical activity in managing anxiety symptoms.

Main Methods:

  • Secondary analysis of 178 individuals with mild to severe anxiety.
  • Random assignment to CBD-dominant, THC-dominant, or THC+CBD cannabis products for 4 weeks.
  • Assessment of negative affect using the DASS-21 and measurement of moderate-to-vigorous physical activity (MVPA) via actigraphy.

Main Results:

  • Negative affect decreased across all cannabis groups over time.
  • A significant interaction revealed that physical activity moderated the decrease in negative affect for the THC-dominant group.
  • Increased MVPA was associated with a less pronounced reduction in negative affect for THC-dominant users, but not for CBD-dominant or THC+CBD users.

Conclusions:

  • This study is the first to demonstrate that physical activity moderates cannabis-associated reductions in negative affect.
  • The observed interaction is dependent on the specific cannabinoid profile of the cannabis product used.
  • Findings suggest a nuanced relationship between cannabis chemovars, physical activity, and anxiety symptom reduction.