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AMPK as a regulatory node in cell death.

Dade Rong1, Shuai You1, Han-Ming Shen1

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Trends in Biochemical Sciences
|March 21, 2026
PubMed
Summary
This summary is machine-generated.

Adenosine Monophosphate (AMP)-activated protein kinase (AMPK) regulates cellular metabolism and various cell death pathways. This review explores AMPK's role in diseases like cancer and diabetes, highlighting therapeutic strategies targeting cell death.

Keywords:
AMPKapoptosisferroptosisnecroptosispyroptosis

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Medicine

Background:

  • Adenosine Monophosphate (AMP)-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis.
  • Emerging evidence highlights AMPK's significant involvement in diverse regulated cell death (RCD) pathways.
  • These RCD pathways include apoptosis, necroptosis, pyroptosis, and ferroptosis.

Purpose of the Study:

  • To comprehensively review the regulatory functions of AMPK in distinct RCD pathways.
  • To investigate the implications of AMPK in major human diseases.
  • To evaluate the therapeutic potential of modulating AMPK activity for disease treatment.

Main Methods:

  • Literature review and synthesis of existing research on AMPK and RCD.
  • Analysis of studies linking AMPK to pathological conditions.
  • Exploration of therapeutic strategies involving AMPK activators and inhibitors.

Main Results:

  • AMPK plays a multifaceted role in controlling the initiation and execution of apoptosis, necroptosis, pyroptosis, and ferroptosis.
  • Dysregulation of AMPK is implicated in the pathogenesis of cancer, diabetic complications, ischemia-reperfusion injury, and infectious diseases.
  • Targeting AMPK offers promising therapeutic avenues for managing these diseases by modulating RCD.

Conclusions:

  • AMPK is a key molecular switch integrating cellular metabolism with regulated cell death.
  • Understanding AMPK's role in RCD provides critical insights into disease mechanisms.
  • Pharmacological targeting of AMPK presents a viable strategy for novel therapeutic interventions in various diseases.