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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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Related Experiment Video

Updated: Jun 11, 2026

Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
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In-utero exposure to chikungunya and child morbimortality: a population-based study using linked routine data.

Mio Kushibuchi1, Orlagh Carroll2, Thiago Cerqueira-Silva2,3

  • 1Centre for Data and Knowledge Integration for Health (CIDACS), Fundação Oswaldo Cruz, Salvador, Brazil. Miokushibuchi0119@gmail.com.

Nature Communications
|March 22, 2026
PubMed
Summary
This summary is machine-generated.

In-utero Chikungunya virus exposure increases infant hospitalization risk, particularly with intrapartum exposure. This study highlights the long-term health impacts on newborns, emphasizing the need for maternal and neonatal care during outbreaks.

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Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Chikungunya virus (CHIKV) infection during pregnancy poses risks to newborns.
  • In-utero CHIKV exposure is associated with neonatal morbidity and potential neurodevelopmental issues.
  • Long-term health outcomes following prenatal CHIKV exposure require further investigation.

Purpose of the Study:

  • To evaluate the long-term morbidity associated with in-utero Chikungunya virus exposure.
  • To quantify the risk of hospitalization and death in infants exposed to CHIKV during gestation.
  • To assess the impact of the timing of CHIKV exposure (trimester, intrapartum) on infant health outcomes.

Main Methods:

  • Registry-based cohort study in Brazil (2015-2018).
  • Linked infant records to track all-cause first hospitalization and death until age three.
  • Utilized adjusted stratified Cox models to estimate hazard ratios (HR) and confidence intervals (CIs).

Main Results:

  • 1,821 CHIKV-exposed and 18,210 unexposed infants were analyzed.
  • In-utero CHIKV exposure showed an elevated hospitalization risk (HR: 1.21, 95% CI: 1.11-1.36).
  • Intrapartum exposure carried a twofold increased risk (HR: 2.08, 95% CI: 1.33-3.44); first and second-trimester exposures also elevated risk. Evidence for increased mortality risk was limited.

Conclusions:

  • In-utero Chikungunya virus exposure is associated with significantly elevated infant hospitalization rates.
  • The timing of exposure, especially intrapartum, influences the severity of health risks.
  • Findings underscore the importance of monitoring and managing CHIKV in pregnant populations to mitigate adverse infant outcomes.