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Updated: Mar 23, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
The most important features in generalized additive models might be groups of features
Tomas Bosschieter1, Luis França2, Jessica Wolk2
1Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, 94305, USA. tomasbos@alumni.stanford.edu.
Abstract:
While analyzing the importance of features has become ubiquitous in interpretable machine learning, the joint signal from a group of related features is sometimes overlooked or inadvertently excluded. Neglecting the joint signal could bypass a critical insight: in many instances, the most significant predictors are not isolated features, but rather the combined effect of groups of features. This can be especially problematic for datasets that contain natural groupings of features, including multimodal datasets. This paper introduces a novel approach to determine the importance of a group of features for Generalized Additive Models (GAMs) that is efficient, requires no model retraining, allows defining groups posthoc, permits overlapping groups, and remains meaningful in high-dimensional settings. We showcase properties of our method on three synthetic experiments that illustrate the behavior of group importance across various data regimes. We then demonstrate the importance of groups of features in identifying depressive symptoms from a multimodal neuroscience dataset, and study the importance of social determinants of health after total hip arthroplasty. These two case studies reveal that analyzing group importance offers a more accurate, holistic view of medical issues compared to a single-feature analysis.
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