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Related Experiment Video

Updated: Mar 23, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

White matter microstructure and its association with visuospatial processing development during early infancy.

Narmin Javadova¹, Marissa Ann DiPiero^2,3, Christy D Yoon²

¹Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.

Scientific Reports

|March 22, 2026

Summary

This summary is machine-generated.

Infant white matter microstructure, measured by diffusion MRI, is linked to later visuospatial processing skills. Early brain development, particularly in the cerebellum and cingulate gyrus, influences these abilities.

Keywords:

Biological sex Cerebellum DTI Diffusion MRI NODDI Visuospatial processing

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Last Updated: Mar 23, 2026

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

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Published on: August 11, 2016

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Published on: September 12, 2011

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

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Published on: November 8, 2012

Area of Science:

Neuroscience
Developmental Psychology
Radiology

Background:

White matter microstructure development in infancy is crucial for cognitive functions.
Visuospatial processing abilities emerge in early childhood and are vital for various tasks.
Understanding the early neural correlates of visuospatial skills can inform developmental trajectories.

Purpose of the Study:

To investigate the relationship between white matter microstructure in one-month-old infants and their visuospatial processing abilities at six months.
To identify specific white matter tracts associated with early visuospatial development.

Main Methods:

Diffusion MRI was used to assess white matter microstructure in 91 infants at one month of age.
Behavioral assessments were conducted at six months of age to measure visuospatial processing.
Statistical analyses, including adjustments for multiple comparisons, were performed to identify significant correlations.

Main Results:

Fractional anisotropy (FA) in the superior cerebellar peduncle and cingulate gyrus correlated with toy play intensity.
Mean diffusivity and axial diffusivity in the superior cerebellar peduncle were associated with gaze shifting.
No significant correlations were found with biological sex after adjustments.

Conclusions:

Developing white matter microstructure, assessed via diffusion MRI metrics, plays a significant role in the development of visuospatial processing.
These findings highlight the importance of early brain structure for emerging cognitive abilities.
Further research is warranted to explore the long-term predictive value of these relationships for visuospatial ability and working memory.